My Take on Estriol Cream for Skin: Subtle Changes, Real Potential

I started using estriol cream at age 47—but honestly, I wish I had gotten a start on a consistent skincare regimen years ago. I’ve always been interested in taking care of my skin, and like many women, I began with tretinoin, which is still my go-to for long-term skin health and aging prevention. I’m also a big fan of a good vitamin C serum—it’s one of my favorite ways to support collagen and brighten the skin.

More recently, I added compounded estriol cream, and after about two months of consistent use, I’m noticing a real difference—especially in my neck, an area that I feel shows signs of aging earlier than the face for many women.

We know that as estrogen levels decline, skin begins to change—losing collagen, elasticity, moisture, and overall resilience. So I wanted to dive into the science behind estriol cream and see what the data tells us about using it as part of a woman’s skincare routine. The studies are small, but the potential benefits are real—and the risk is low for most women.

My favorite compounding pharmacist makes my estriol cream with or without hyaluronic acid, which is a powerful hydrator. But here’s the caveat: in dry Minnesota winters, hyaluronic acid can sometimes do the opposite of what you want. If it can’t pull moisture from the air, it’ll pull it from your skin—so make sure to pair it with a rich moisturizer or avoid it during the driest months.

So, What Is Estriol?

Estriol is a weaker form of estrogen that’s often used in topical creams to support aging skin. Because it acts locally, it usually has minimal absorption into the bloodstream, making it a great option for women who want to address skin changes without committing to systemic hormone therapy.

What the Research Tells Us

1. Collagen Support and Thicker Skin

Estriol stimulates production of collagen types I and III, which help maintain structure and firmness. A small study in women ages 45–55 found that 24 weeks of topical estrogen use (including estriol) led to improved collagen levels and thicker skin—helping to counteract the thinning that often comes with menopause.

2. Better Elasticity and Firmness

In a study from the University of Vienna, postmenopausal women who used a 0.3% estriol cream for six months saw significant improvements in skin elasticity and tone, with wrinkle depth and pore size decreasing by up to 60–100%. This is thought to be due to estriol’s effect on fibroblasts, the cells responsible for producing collagen and elastin.

3. Improved Hydration (With a Seasonal Note)

Estriol may increase skin hydration by boosting both sebum and hyaluronic acid production. Many users report a noticeable improvement in dryness and skin plumpness. Just remember that hyaluronic acid needs moisture in the air to work—so if you’re using a cream that includes it, apply it with a heavier moisturizer or avoid it during extremely dry weather.

4. Fewer Fine Lines and Wrinkles

Studies suggest that fine lines and wrinkles can soften with consistent use of estriol cream—especially after 12 weeks or more.

5. Minimal Systemic Absorption

One of the biggest advantages of estriol cream is that it acts locally. Most studies show that it doesn’t significantly raise estrogen levels in the bloodstream. Some minor increases in prolactin have been observed, but no major hormonal changes have been reported.

6. Possible Side Effects

While generally well-tolerated, some women may experience:

Pigmentation changes like melasma, especially without sun protection
Mild irritation
A lack of long-term safety data in younger women or those with normal estrogen levels

Is Estriol Cream Right for You?

Estriol creams are typically prescription-only in the U.S. and are most appropriate for perimenopausal and postmenopausal women noticing skin changes like dryness, dullness, or sagging.

Everyone’s skin is different, but many women see noticeable improvements in texture, hydration, and firmness after a few months of consistent use. For me, the neck was the first place I noticed subtle but steady change—and I’m excited to keep watching.

Ready to Take the Next Step in Your Skincare (and Hormone) Journey?

If you’re in your 40s or 50s and noticing changes in your skin, you’re not imagining it—estrogen really does play a major role in skin health. Whether you’re curious about estriol cream, wondering what’s safe and effective during perimenopause, or just want to feel like yourself again, I’d love to help.

At my clinic, we take a personalized, symptom-focused approach to menopause care. That includes thoughtful conversations about skin, sleep, mood, hormones, and everything in between. You don’t need perfect labs to start feeling better—and you don’t have to figure it out alone.

Let’s talk about what’s right for you.

Book a consult here to get tips, updates, and education on all things midlife, hormones, and skin health.